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ANP (1-28); Carperitide,Catalog Number: KS062018,CAS NO.: 89213-87-6

SKU. 172568

$ 346

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Atrial natriuretic peptide (ANP) is an endogenous peptide generated by proteolysis of prepro-ANP that is secreted by cardiomyocytes in the heart. It has effects on the renal and cardiovascular systems that decrease vasoconstriction, inhibit renin secretion, and increase sodium excretion. Human ANP binds to ANP receptors on cultured vascular smooth muscle cells (VSMCs) with a Kd value of approximately 1-2 nM and increases cGMP levels in a dose-dependent manner. It relaxes potassium-induced contraction of isolated canine renal arterial strips when used at concentrations of 10 and 100 ng/ml and dilates renal arteries in anesthetized dogs when used at doses ranging from 10 to 100 ng/kg. In a rat model of heart failure following experimental autoimmune myocarditis, human ANP, via osmotic mini pump for 28 days, decreases cardiomyocyte size as well as the amount of cardiac fibrosis and left ventricular remodeling.5 ANP (1-28) (human) is a 28 amino acid peptide corresponding to the human protein sequence.

Catalog Number KS062018
Product Name ANP (1-28); Carperitide
Sequence SLRRSSCFGGRMDRIGAQSGLGCNSFRY-OH (Cys7 and 23 bridge)
CAS NO. 89213-87-6
price/1mg $346
Purity ≥95% (HPLC)
Molecular Formula C₁₂₇H₂₀₃N₄₅O₃₉S₃
Molecular Weight 3080.49
Form Lyophilized
Storage Store at -20°C or -80°C

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