H3K56ac DNA Histones Proteins Catalog Number H3201

SKU. 172680

$ 22.82

Stock:: 500 in Stock

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H3-K56ac Catalog Number H3201 Lyophilized Store At -20°C Or -80°C

Chemically synthesized histone H3 protein, corresponding to residues within 1-135 of human histone H3, acetylation at K56.

H3K56ac is a covalent modification known as a mark of newly replicated chromatin as well as replication-independent histone replacement. H3K56ac is important for chromatin remodeling and serves as a marker of new nucleosomes during DNA replication but its role in the cell cycle is debated. Lysine 56 is located at the amino-terminal αN-helix and close to the site where the DNA enters and exits the nucleosome. Due to its location on the lateral surface of the nucleosome, which is close to the DNA entry/exit site and interacts with DNA. The studies on yeast might not apply to mammals. Mammalian cells do not express HATs with high specificity to K56. Sirtuins can catalyze the removal of the acetyl group from K56. H3K56ac levels are elevated in cancer and pluripotent cells. TRIM66 reads unmodified H3R2K4 and H3K56ac to respond to DNA damage.

Catalog Number H3201
Product Name H3-K56ac
Scale 50 μg
Purity ≥95%(HPLC)
price $1141
CAS#. N/A
Sequence ARTKQTARKS TGGKAPRKQL ATKAARKSAP ATGGVKKPHR YRPGTVALRE IRRYQKSTEL LIRKLPFQRL VREIAQDFKT DLRFQSSAVM A
Molecular Formula C₆₇₁H₁₁₃₁N₂₁₅O₁₈₆S₄
Molecular Weight 15314.89
Form Lyophilized
Storage Store at -20°C or -80°C

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