Shipping calculated at checkout.
Potent, specific L-type Ca2+ channel blocker (IC50 = 15 nM). Inactive on other voltage-dependent Ca2+ channels. Smooth muscle relaxant and cardia contraction inhibitor. Neurotoxic. Active in vivo and in vitro.
Calciseptine (CaS) is a natural neurotoxin isolated from the black mamba Dendroaspis p. polylepis venom. This toxin consists of 60 amino acids with four disulfide bonds. Calciseptine specifically blocks L-type calcium channels, but not other voltage-dependent Ca2+ channels such as N-type and T-type channels
History
The black mamba (Dendroaspis polylepis) is generally considered to be one of the deadliest snakes on the planet,and is responsible for many fatalities throughout its sub-Saharan Africa range. Without treatment, the bite of a Black Mamba causes a 100% mortality rate.
The venom of the Black Mamba consists of more than 28 peptides. One of these peptides is calciseptine. It makes up 2.8% of the venom of the Black Mamba. When first purified, the peptide was called protein E3, which was later changed to calciseptine by Weille et al.
Sequence and structure
Calciseptine itself consists of 60 amino acids and has been fully sequenced:
RICYIHKASL PRATKTCVEN TCYKMFIRTQ REYISERGCG CPTAMWPYQT ECCKGDRCNK
The three-dimensional structure of calciseptine has not been determined experimentally. However, another toxin found in black mamba venom, called FS2, sequentially differs from calciseptine in only three residues: it contains a serine instead of isoleucine in position 5, a histidine instead of glutamine in position 30, and a glutamine instead of glutamic acid in position 32. A three-dimensional structure of FS2 has been determined using NMR, and because of the minor sequential differences, this can serve as a model of the calciseptine structure
Our products are shipped from China, the dispatching date will be commenced in few business days after the finishing of QC from the related department.
Detailed tracking information will be offered to your mailbox in an automatic manner as long as we officially dispatched your package from our sorting center.
Customer is advised to check more tracking information from “My Account” after the account sign in.
It occasionally comes to the situation for no displaying of tracking information after the receiving of shipment notification. Please be advised to wait for 1-2 business days until the updating of pertinent tracking information in your account center.
Expedited shipment
The changing of the shipping methods may have occurred when we are noticed from customer for the needing of rush order or lower rate of shipment delay. The related request is acceptable whenever in prior of the order is dispatched and heading to the designated shipping address.
Note: (PO) boxes or FPO/APO military addresses can only be shipped out by standard shipping method).
The shipping fare for the expedited shipment method may higher than the standard one you chose for, then please be aware that you may ask to pay for the balance for the pertinent shipment substitution. You are welcome to contact our customer service via “contact us” for further inquiry and requisition
Shipping cost all about
It is deeply appreciated to take your kind pardon for any misunderstanding about the shipping price due to the package is shipped from China.
The contract we have stipulated with FedEx, DHL, UPS and EMS is already set and therefore all merchandise is sent via Air rather than Ground. While this may not be the most cost effective for all customers, in terms of delivery time, ease of shipment and reliability we have determined that this is the most effective overall.
The shipping cost for all merchandises are displayed by adding items to your shipping bag, you can estimate shipping time and cost and acquire more shipping cost information from our site.
International Shipping
International shipping costs are calculated in U.S. currency based on estimated shipment weight and destination. Shipping costs for orders placed on the website are fairly accurate, but there are times when those estimates are incorrect. If we need to adjust shipping charges for your order we will contact you to authorize those additional shipping charges.
Please enter your target price
Please provide a quantity
United States
Please provide your name
Please enter your email adress
Enter a valid email address
Please enter the phone number
Please enter the inquiry information
Iberiotoxin Peptide Toxins CAS 129203-60-7 Catalog Number K1060-V
KS-V huwentoxin IV CAS 526224-73-7 Catalog Number N1020-V
α-conotoxin Ml Antagonist Catalog Number O1070-V CAS 83481-45-2
α-Conotoxin GI Peptide Toxins Catalog Number O1050-V CAS 76862-65-2
Alpha α-Conotoxin Lml Peptide Toxins Catalog Number O1060-V
Muscarinic Toxin 7 Peptide Toxins Catalog Number O1110-V
3FTx Mambalgin-2 Snake Venom Peptide Catalog Number O1020-V
Kaliotoxin Potent blocker CAS 145199-73-1 Catalog Number K1070-V
Margatoxin Peptide CAS 145808-47-5 Catalog Number K1020-V
SNX482,CAS#:203460-30-4,Lyophilized,Catalog Number: C1080-V
Lyophilized Protoxin II CAS 165168-50-3 Catalog Number N1030-V
Bee Venom Tertiapin-Q Blocker Catalog Number K1120-V
Lyophilized scorpion Kurtoxin CAS 820959-57-7 Catalog Number C1090-V
Charybdotoxin Peptide Toxins Inhibitor CAS 95751-30-7 Catalog Number K1080-V
ShK Toxin Peptide Toxins CAS 172450-46-3 Catalog Number K1010-V
GxTx-1E Peptide Toxins Catalog Number K1110-V
LINK-PP LPJ1075-1BHNL 100% Cross RTA-110AHQ1A UDE
United States
Carrier
CostDelivery TimeTracking
Fedex IP
$ 44.65 0-27 daysAvailable
Calciseptine,Channel Type:Ca2+ Channel Blocker,CAS#:178805-91-9