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GsMTx-4 Peptide Toxins Catalog Number O1080-V CAS 1209500-46-8

SKU. 173018

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GsMTx-4,Catalog Number: O1080-V,CAS#:1209500-46-8,Lyophilized,Purity≥95%

Mechanosensitive and stretch-activated ion channel inhibitor.

Grammostola mechanotoxin #4 (GsMTx-4, GsMTx4, GsMTx-IV), also known as M-theraphotoxin-Gr1a (M-TRTX-Gr1a), is a neurotoxin isolated from the venom of the spider Chilean rose tarantula Grammostola spatulate (or Grammostola rosea).This amphiphilic peptide, which consists of 35 amino acids, belongs to the inhibitory cysteine knot (ICK) peptide family. It reduces mechanical sensation by inhibiting mechanosensitive channels (MSCs).

GsMTx-4 also serves as a cationic antimicrobial peptide against Gram-positive bacteria.

Source.

GsMTx-4 was isolated from the venom of Grammostola spatulata. After a blocking effect on mechanosensitive channels of the spider venom was detected in 1996, GsMTx-4 was isolated and identified from the venom later in 2000. Its concentration in the venom is ∼2 mM.

Catalog Number O1080-V
Product Name GsMTx-4
Scale 50 μg
price $139
Purity ≥95%
Channel Type Other Blockers
Sequence GCLEFWWKCNPNDDKCCRPKLKCSKLFKLCNFSF
Molecular N/AFormula C₁₈₅H₂₇₃N₄₉O₄₅S₆
Molecular Weight 4095.2 Da
Form Lyophilized
Storage Store at -20°C or -80°C

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